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In a typical adult, the gut microbiota contains approximately 3.8 × 10¹³ bacterial cells—about ten times the number of human cells—and its genetic material exceeds the human genome by 30-fold, highlighting its immense metabolic potential (Li et al., 2014

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In a similar line, epigenetic treatments including agents targeting DNA methylation (e.g., decitabine), histone modifications (e.g., HDAC inhibitors), and RNA methylation (m6A modulators) are emerging as beneficial complements to chemotherapy and immunotherapy [61,77]